Last Man Alive is an interactive telling of the last living human's last fifteen minutes alive. Earth is devastated by nuclear holocaust, presumably wiping out all life on the planet. The player controls Jerry Lewis, an astronaut aboard the Second International Space Station, as he wanders about the station waiting for his oxygen to run out. Interaction in the game comes in the form of text boxes which appear when the player examines certain objects on the station. There is no way for the player to save Jerry from his certain demise, and the player has a limited amount of time to explore, making it impossible to experience all the interactions available in a single playthrough.